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Taquilo's Tex-Mex Cantina is located in the heart of downtown Galveston at the corner of Postoffice Street and 21st. The eatery is part of Galveston Restaurant Group, a locally-owned company that has brought the “art of good eating” to patrons since 1997. Created by Johnny Smecca, Joey Smecca and Danny Hart, they opened their first restaurant, Saltwater Grill, in 1998, located in the heart of the Galveston Arts & Entertainment District.

Additional Galveston Restaurant Group properties include Papa's Pizza, The Gumbo Diner, Mario's Seawall Italian Restaurant, Little Daddy's Gumbo Bar, and Sky Bar Steak & Sushi.