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UTMB Researchers Find How Ebola Disables the Immune System

Updated 697 days ago

A new study at The University of Texas Medical Branch in Galveston sheds light on how Ebola so effectively disables the human immune system.

Virologist Alex Bukreyev, UTMB professor and senior author of the study, said the research team engineered versions of the Ebola virus in order to study how the components responsible for thwarting or disabling our immune defenses wreak their havoc. The findings are described in the new edition of PLOS Pathogens.

For the past 16 years, there has been an extensive investigation of how the Ebola virus operates when it invades a new host such as a human and how it interferes with interferons - specialized signaling proteins that are made and released in response to an invasion by a virus or other pathogen. Interferons directly inhibit replication of viral particles in cells. A focus of this research has been how Ebola gets around the host’s cell-mediated immune response, which is another defense mechanism involving some specialized immune cells that either kill virus-infected cells or secrete antibodies that directly neutralize the virus.

Previous studies have identified two protein regions within the Ebola virus’ structure called interferon inhibiting domains, or IIDs, that prevent the host’s interferons from doing their job thus disabling the host’s immune system defenses. As a result, these IIDs promote replication of the virus within the host. However, researchers have assumed that IIDs only inhibit the effects of interferons – until now.

The study used genetically altered strains of the Ebola virus that were designed with one or both of the IID’s disabled to study what they do to the host. The altered viruses were placed on specific types of immune cells isolated from human blood, called dendritic cells, T lymphocytes, B lymphocytes and natural killer cells, as these types of cells are key players in marshaling defenses.

“We found that IIDs work not only in ways previously established, which includes interference in cascades of protective biochemical reactions that occur in cells in response to Ebola that limit infection”, Bukreyev said. “The IID’s also counter the activity of immune cells, including T lymphocytes and natural killer cells that kill virus-infected cells as well as B lymphocytes that secrete antibodies.” “It’s a double edged sword - the IIDs not only block interferon signaling, they also prevent infected cells from activating the cell-mediated arm of the immune response,” said Patrick Younan, research scientist and co-lead author of the paper. “You take away these functions of Ebola virus and the immune system should clear the infection.“

Bukreyev said, “taken together, the findings suggest that Ebola IIDs have a global dampening effect on the host’s ability to fight off the impending Ebola infection, and also indicate the potential benefits of blocking the immunosuppressive effects of IIDs as a potential therapy for Ebola infection.”

Other authors include UTMB’s Ndongala Michel Lubaki, Rodrigo Santos, Michelle Meyer and Mathieu Iampietro as well as Richard Koup from the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, who served as a consultant.

About UTMB Health:
Texas' first academic health center opened its doors in 1891 and today comprises four health sciences schools, three institutes for advanced study, a research enterprise that includes one of only two national laboratories dedicated to the safe study of infectious threats to human health, a Level 1 Trauma Center and a health system offering a full range of primary and specialized medical services throughout Galveston County and the Texas Gulf Coast region. UTMB Health is a part of the University of Texas System and a member of the Texas Medical Center.

Article written by Raul Reyes

Raul Reyes, director of media relations at UTMB, has an extensive background in communications with more than 30 years experience in journalism. Before joining UTMB in 2007, he was an editor at The New York Times and also worked as an editor at the Dallas Morning News and the San Antonio Express-News. When he and his wife, Linda, worked at the Houston Chronicle in the 1980s, they used to dream about living and working in Galveston. Some things do come true. Raul is at UTMB and Linda edits a couple of Dallas magazines from their home in Galveston.

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