Travel Interstate 45 South (Gulf Freeway) to the Galveston Causeway. Soon after crossing the Causeway, I-45 becomes Broadway (SR-87, Ave. J). Continue traveling along Broadway for approximately 2.8 miles. Turn left on 24th St. and travel north approximately .3 miles to Church Street. Turn left onto Church St. travel approximately .1 mile to 25th St. Turn right onto 25th. Travel approximately .4 miles. The Railroad Museum is on the left.
From Bolivar Peninsula:
Starting from Crystal Beach, travel approximately 10.7 miles to the Bolivar Ferry. Upon exiting the Ferry, take Ferry Road (SR-87) and head southeast approximately .9 miles. Turn right (west) onto Harborside Drive and travel approximately 1.6 miles. Turn left (south) onto 25th Street. The Railroad Museum is on the right.